NAME OF COURSE/MODULE: CELL & MOLECULAR BIOLOGY
COURSE CODE: SBS3053
NAME(S) OF ACADEMIC STAFF: DR HANINA MOHD NOOR / DR MARYAM MOHAMED REHAN / DR MOHD NAZMI ABD MANAP
RATIONALE FOR THE INCLUSION OF THE COURSE/MODULE IN THE PROGRAMME: Biology is today in the midst of a revolution as a result of recent research into the molecular basis of life. An understanding of the theory and techniques of molecular biology are now becoming essential to many diverse areas of study in biology, from the study of biodiversity and evolutionary relationships to genetic engineering of microbes, plants and animals. The principal aim of this course is to introduce the students to classical and modern concepts in cell and molecular biology. Laboratory experiments will reinforce the lecture and give a hand’s on understanding of several techniques used in cell and molecular biology laboratories.
SEMESTER AND YEAR OFFERED: SEM 1 / YEAR 3
TOTAL STUDENT LEARNING TIME (SLT) FACE TO FACE TOTAL GUIDED AND INDEPENDENT LEARNING
L = Lecture

T = Tutorial

P = Practical

O= Others

L

24

T

 

0

P

 

18

O

 

78

L + T + P + O = 120 HOURS

CREDIT VALUE: 3
PREREQUISITE (IF ANY): NONE
OBJECTIVES:
  1. To effectively discuss the fundamental concepts and underlying processes related to cellular and molecular biology.
  2. To provide an understanding of the current key topics and technologies in the molecular and cellular biology area.
  3. To apply, implement and practise laboratory experiences and technical skills necessary for conducting final year research project.
  4. To work independently and collaboration with others to compile, analyze, interpret, and present scientific data using oral and written formats.
LEARNING OUTCOMES:

 

Upon successful completion of this course students should have the ability to:

1.     Study and explain the chemical basis of life based on the correlation of structures of biomolecules such as proteins, polysaccharides and lipids with their respective physicochemical properties and biological functions (C2, A3 – LO1).

2.     Explain the flow of genetic information from DNA to RNA to protein, and the relationship between the nucleotide sequences of DNA and RNA with the amino acid sequences of proteins (C2, A3 – LO1).

3.     Compare and contrast as well as differentiate the molecular mechanisms of DNA replication, transcription, gene regulation and translation in prokaryotes and eukaryotes (C4 – LO1).

4.     Construct and develop the technical and analytical skills necessary to work on a research final year project (P4 – LO2, LO3).

5.     Construct and report the experimental results in a thesis written formats (P4, A2 – LO3).

TRANSFERABLE SKILLS: Students should be able to develop problem solving and analytical skills through a process of lectures and practical.
TEACHING-LEARNING AND ASSESSMENT STRATEGY:

 

Teaching-learning strategy:

The course will be taught through a combination of formal lectures, laboratory practical, group work, using authentic materials, informal activities and various textbooks.

Assessment strategy:

  1. Formative
  2. Summative
SYNOPSIS:

 

This course will provide an introduction to cell and molecular biology.  It will emphasize the molecular mechanisms of DNA replication, transcription, and gene regulation in prokaryotes and eukaryotes as well as membrane function and cellular communication. The course provides students with the basic information and foundation of the molecular processes and genetic phenomena in both prokaryotic and eukaryotic cells. The approach taken in this course is to explain the systems that must continually be referred to in order to understand molecular phenomena. Topics of subjects include cell membrane structure and function, molecular aspect of cell division and cell cycle, cellular communication structure and properties of nucleic acids, DNA replication, molecular biology of gene expression and its regulation in prokaryotes and eukaryotes, transcription and RNA processing (splicing), transcriptional and post-transcriptional control mechanism, protein structure and translational control.  Basic techniques of molecular biology used in study of gene structure and function including DNA/RNA or plasmid isolation from bacteria, agarose gel electrophoresis, restriction enzyme analysis and PCR (Polymerase Chain Reaction) are covered during laboratory practicals.
MODE OF DELIVERY: Lecture and laboratory practical.
ASSESSMENT METHODS AND TYPES:
A. Continuous Assessment (40%)
Category Percentage Assessment Method
Cognitive

Practical Skills

Communication Skills

Team Work and Ethics

30%

5%

5%

·         Midterm Test

·         Procedural & Manipulative Skills

·         Lab Reports

B. Final Examination (60%)
Examination 60% ·    Multiple Choice Questions

·    Structure type questions

·    Essay type questions

MAIN REFERENCES SUPPORTING THE COURSE
  1. Weaver, R.F. 2008. Molecular Biology. (4th Edition). New York : McGraw. Hill Higher Education.
  2. Campbell, N.A. & Reece, J.B. 2008. Biology. 8th Edition. San Francisco : Pearson Benjamin Cummings
ADDITIONAL REFERENCES SUPPORTING THE COURSE
  1. Karp, G. 2008. Cell and Molecular Biology : Concepts and Experiments. (5th Edition). Asia : John Wiley & Sons.
  2. Campbell, N.A. & Reece, J.B. 2005. Biology. 7th Edition. San Francisco : Pearson Benjamin Cummings
  3. Turner, P.C., A.G. McLennan, A.D. Bates & M.R.H. White. 2000. Instant Notes in Molecular Biology. (2nd Edition). London& New York : BIOS Scientific Publishers.
  4. Watson, J.D., T.A. Baker, S.P. Bell, A. Gann, M. Levine & R. Losick. 2004. Molecular Biology of the Gene.  (5th Edition). USA : Pearson Benjamin Cummings.
  5. Elliot, W.H. & D.C. 2005. Biochemistry and Molecular Biology. (3rd Edition). Oxford :OxfordUniversity Press.