1. NAME OF COURSE  / MODULE PHARMACOLOGY
2. COURSE CODE PAD3016
3. NAME(S) OF ACADEMIC STAFF
  • Dr. Zetty Nadia Mohd Zain (Course coordinator)
  • Dr. Khairun Nain Nor Aripin
  • Assoc. Prof. Datin Dr. Sharida Fakurazi
  • Prof. Dr. Kamsiah Jaarin
  • Dr. Qodriyah Mohd Saad
  • Prof. Dr. Norazlina Mohamed
  • Prof. Dr. Nazrul Hakim Abdullah
  • Prof. Dato’ Dr. Nik Nasri Nik Ismail
4. RATIONALE FOR THE INCLUSION OF THE COURSE/MODULE IN THE PROGRAMME   Basic medical science course
5. SEMESTER & YEAR OFFERED Semester 1 and 2/ Year 3
6. TOTAL STUDENT LEARNING TIME (SLT) Face to face:

L T P/S O
50 38 38 7

L=lecture ;  S=Seminar;   O=Others (Exam)

Total Guided and Independent Learning:

133+113=246
7. CREDIT VALUE 246/40 weeks = 6.15
8. PREREQUISITE (IF ANY)
9. OBJECTIVES By the end of the course, the students are expected to :

  1. Understand the basic concepts and principles of pharmacology and its relation to clinical practice.
  2. Recognize the appropriate and common treatment for a specific disease.
  3. Apply the knowledge in drugs’ pharmacokinetics and pharmacodynamics in deciding the best and safe treatment for patients.
10. LEARNING OUTCOMES Upon completion of this course, students will be able to:

  1. Explain the mechanism of drug actions and the adverse effects of the commonly used drugs (LO1, C3)
  2. Explain the rationale of the use of drugs in treatment of diseases (LO3-CTPS, A3)
  3. Explain the toxicity of drugs and chemical substances and describe methods of protections and management of the toxic manifestations (LO7, P3)
11. TRANSFERABLE SKILLS
  • Recognize various drugs available to treat various conditions
  • Predict the possible adverse effects that may occur with the use of each drug
  • Critical thinking and problem solving
  • Effective communication
  • Teamwork
  • Lifelong learning
12. TEACHING-LEARNING AND ASSESSMENT STRATEGY Teaching-learning strategy:

The course will be taught through a combination of lectures, tutorials, seminars,  computer-aided learning sessions, discussions and PBL using clinical scenario or problem solving materials. Collaborative teamwork will be fostered throughout the course. The use of in class individual and group presentation or discussion will assess the student’s ability to apply critical thinking and encourage students to respond and participate actively in class. Students will also study using self learning packages (SLP).

 Assessment strategy:

  • Summative assessment  (mid-semester 2 and end semester 1 examination)
  • Second professional examination
13. SYNOPSIS The medical pharmacology course spans over 2 semesters in year 3. It will introduce the students to the main drug classes together with their prototypes, mechanism of actions, benefits to patients, basic pharmacokinetic properties, specific clinical uses and possible adverse effects. There is also teaching on drug interactions, adverse drug reactions and prescribing practice. This knowledge should prepare them to further understand therapeutic applications of drugs when they start their clinical rotations, as well as to train them to become doctors who use drugs safely and effectively in their careers. Delivery of pharmacology knowledge will be via lectures, tutorials and practical classes. Students are also expected to obtain knowledge via student-centred learning methods such as by using self learning packages (SLPs) and by preparing and participating in seminars. Computer-aided learning (CAL) packages are also made available to the students. The students are assessed through continuous formative and summative assessments which include multiple choice questions, one best answer questions and short essay questions. The continuous assessment is worth 30 % (one exam at the end of semester 1 and mid-semester exam in semester 2) and the final professional examination is worth 70 % at the end of year 3.
14. MODE OF DELIVERY Lectures, Tutorial (SCL), Computer-aided learning (CAL), Seminars
15. Assessment methods and types
Summative Assessment (100%)
Category Percentage Assessment method
End Semester 1 Examination

 

22.5%

 

Multiple Choice Questions (OBA, EMI, TF)

Modified Essay Questions

 

Mid semester 2 Examination

 

7.5% Multiple Choice Questions (OBA, EMI, TF)

 

Second professional examination

 

70% Multiple Choice Questions (OBA, EMI, TF)

Modified Essay Questions

16. MAPPING OF THE COURSE/MODULE TO THE PROGRAMME AIMS Rujuk Lampiran A
17. MAPPING OF THE COURSE/MODULE TO THE PROGRAMME LEARNING OUTCOMES Rujuk Lampiran B
18. Content outline of the course/module and SLT per topic
Topics FACE TO FACE SELFSTUDY TOTAL SLT
Lecture Tutorial Assessment/ Practical Seminar SLP SDL Self-study
A. General pharmacology
i. Introduction to pharmacology ii. Routes of drug administration and membrane transport  iii. Drug absorption and distributioniv. Drug metabolism and kinetics of eliminationv. Time course of drug effects

vi. Mechanisms of drug action & receptor pharmacology

vii. Nature of drug responses

viii. Factors affecting drug response

8 4 4 16 32
B.  Autonomic pharmacology

i. Basic autonomic pharmacology

ii. Direct & indirect cholinomimetic agents

iii. Antimuscarinic drugs & drugs acting on autonomic ganglia

iv. Adrenoceptor agonist

v. Adrenoceptor antagonists

vi. Sympathetic and parasympathetic drugs

vii. Neuromuscular blocking agents

7 4 4 15 30
C. Cardiovascular pharmacology

i. Antihyperlipidemic

ii. Antihypertensive drugs

iii. Antianginals

iv. Drugs used in heart failure

 v. Antiarrhytmic drugs

 vi. Acid base balance & diuretic drugs

6 4 4 12 26
D. Autocoids and related agents

   i. Antipyretic analgesia & NSAIDS

   ii. Antigout agents (SLP)

1 2 2 5 10
E. Drugs used in blood related disorders

i. Anticoagulants & fibrinolytics agent

ii. Drugs used in anaemia (Seminar)

1 2 2 5 10
F. Drugs affecting the gastrointestinal system

i. Drugs used in peptic ulcer disease

ii. Drugs used in the management of constipation, diarrhoea and vomiting (SLP)

1 2 2 5 10
G. Respiratory Pharmacology

i. Drugs used in bronchial asthma

ii. Antihistamine & drugs used for cough (SLP)

1 2 2 2 7 14
H. Drugs acting on the central nervous system
i. Sedative- hypnoticsii. Antiepilepticiii. Antiparkinsonian drugs (SLP)iv. Antidepressants

v. Antipsychotics

vi. Opioid agonist and antagonists

vii. Local anesthetics

viii. General anesthetics

   ix. Drugs of abuse, addiction (Seminar)

7 6 4 2 2 21 42
I. Chemotherapeutic drugs

i. Principals of chemotherapy and antimicrobial therapy

ii. Beta lactam antibiotics

iii. Tetracyclines & chloramphenicol

iv. Aminoglycosides & macrolide

v. Fluroquinolones, sulphonamide & trimethoprim

vi. Antifungal agents

vii. Antiviral agents

viii. Antituberculous agents

8 6 14 28
J. Drugs used in endocrine disorders

i. Hypothalamic and Pituitary hormones

ii. Drugs used in hyperthyroidism

iii. Adrenocorticosteroids & analogue

iv. Female sex hormones & contraceptives

v. Male sex hormones & anabolic steroids

vi. Insulin and oral hypoglycaemic agents

vii.Drugs used in osteoporosis  (SLP)

6 4 2 10 22
D.  Other drugs

i. Vitamins (SLP)

ii.Hepatotoxic and nephrotoxic drugs

1 2 2 5 10
E.  Rational prescribing

i. Drug interactions & Adverse drug reactions

ii. Rational Prescribing: Therapeutic decision-making

iii. Practical Prescribing: Prescribing practice

3 4 5 12
Total  50 38 22 4 12   120 246
19. 1.     MAIN References SUPPORTING THE COURSE

2.     ADDITIONAL REFERENCES SUPPORTING THE COURSE

  • Rang, H.P., Dale, M.M., Ritter, J.M. and Flower, R.J. 2011.  Rang and Dale’s Pharmacology. Churchill Livingstone, 7th Edition.
  • Katzung, B.G. Basic & Clinical Pharmacology. 2012. Lange Medical Publications,  12th Edition
  • Brunton, L.L. 2011. Goodman & Gilman’s The Pharmacological Basis of  Therapeutics. 12th Edition. McGraw Hill
  • KD Tripathi. 2008.  Essentials of Medical Pharmacology. 6th Edition. Unipress Medical Malaysia.
20. OTHER ADDITIONAL INFORMATION Computer-aided learning:

  • Expharmpro
  • PharmaCALogy

 

Mapping of the course/module to the Programme Learning Outcomes

Topic Contact hours (week) Lesson Learning Outcome PLO KI Teaching & Learning Activities Assessment Tasks
Semester 1

  • General pharmacology
  • Autonomic pharmacology
  • Cardiovascular drugs
  • Autocoids
  • Respiratory pharmacology
  • Drugs affecting the gastrointestinal system
  • Drugs used in blood related disorder

Semester 2

  • CNS pharmacology
  • Chemotherapeutic drugs
  • Drugs used in endocrine disorder
  • Other drugs: vitamins, hepatotoxic drugs
  • Rational prescribing
 

Sem1

4 hours (wk 1- wk20)

 

 

 

 

 

 

 

Sem2

4 hours

(wk1-wk19)

1.     Explain the principles, mechanism of drug actions and the adverse effects of the commonly used drugs(C3)  LO1 Interactive lecture

tutorial

computer-aided learning

PBL

Seminar

SLP

MCQ

MEQ

2. Justify the rationale use of drugs in the treatment of patients in accordance with Islamic principles(A3) LO3 Interactive lecture

tutorial

computer-aided learning

PBL

Seminar

SLP

MCQ

MEQ

3. Explain the toxicity of drugs and chemicals, the methods of protections and the management of the toxic manifestations (P3) LO7  CTPS Interactive lecture

tutorial

computer-aided learning

PBL

Seminar

SLP

MCQ

MEQ