1. NAME OF COURSE  / MODULE  BIOCHEMISTRY III
2. COURSE CODE PAB2017
3. NAME(S) OF ACADEMIC STAFF Prof. Dr. Nor Aripin Shamaan

Dr. Nazefah Abdul Hamid

Dr. Wan Noraini Wan Sulaiman

Dr. Nur Farihah Manzor

En. Faizul Helmi Addenan

En. Azhari Abd Aziz

4. RATIONALE FOR THE INCLUSION OF THE COURSE/MODULE IN THE PROGRAMME Basic medical science course
5. SEMESTER & YEAR OFFERED Semester 1 & 2 / Year 2
6. TOTAL STUDENT LEARNING TIME (SLT) Face to face:

L T P/S SLP/SDL SL O
48 36 27 12 150 8

L=lecture ; T=Tutorial; P=Practical; O=Others (Exam)

Total Guided and Independent Learning:

        281
7. CREDIT VALUE 281/40=7.02
8. PREREQUISITE (IF ANY) BIOCHEMISTRY I  (PAB 1013) AND BIOCHEMISTRY II  (PAB 1023)
9. OBJECTIVES The course objectives are;

1.     explain biochemical processes such as digestion and absorption of nutrients, conversion of nutrients into energy, metabolism of the major nutrients

2.     describe the control and regulation of metabolism in the human body

3.     describe metabolic disorders and inherited diseases related to the major nutrients in the human body

10. LEARNING OUTCOMES At the end of the course, students are able to:

1.     explain normal and abnormal metabolic processes, its control and regulation in  the human body (LO1  C2)

2.     perform biochemical laboratory tests. (LO2  P2)

3.     relate biochemical concepts to disorders of the human body (LO3 A4)

11. TRANSFERABLE SKILLS Conduct basic biochemical tests

Interpretation of basic biochemical examination results

Effective communication

Critical thinking and problem solving

12. TEACHING-LEARNING AND ASSESSMENT STRATEGY Teaching-learning strategy:

The course will be taught through a combination of lectures, formal tutorial, exercise, group work, using authentic situational or problem solving materials and self directed learning packages. Collaborative teamwork will be fostered throughout the course. The use of in class individual and group presentation or discussion will assess the student’s ability to apply critical thinking and encourage students to respond and participate actively in class.

  • Interactive sessions
  • Hands-on sessions
  • Directed-self learning

Assessment strategy: 

  • Formative and summative assessment (end semester and professional examination)
13. SYNOPSIS This course covers topics such as the digestion and absorption of biomolecules, the metabolism of carbohydrates, amino acids and lipids, the conversion of biomolecules to energy via electron transport chain and oxidative phosphorylation, metabolic disorder of each biomolecules in selected clinical cases, and biosynthesis and action of hormones and their regulation. The understanding and application of nutrition in clinical perspective is emphasized.  Students are expected to understand molecular biology and genetics in medicine and relate to clinical disorders. Discussion on clinical chemistry of homeostasis, acid base imbalance, liver function and its disorder will be carried out. Students are also expected to perform basic biochemical techniques in diagnosis of certain conditions.
14. MODE OF DELIVERY Lecture, Tutorial, Practical, Seminar, Self-learning package, Tutorial.
15. Assessment methods and types
Summative Assessment (100%)
Category Percentage Assessment method
Continous Assessment Semester 1 25% MCQ
End Semester 1 Examination 50% MCQ, MEQ
Continous Assessment Semester 2 25% MCQ
First Professional Examination. 70% MCQ, MEQ, OSPE
16. Content outline of the course/module and SLT per topic
Topics FACE TO FACE SELF-STUDY TOTAL SLT
Lecture Tutorial Practical/ SCL Assignment/ SLP /SDL Library search Self-study
INPUT 1:    BIOLOGICAL OXIDATION

 

2 4 6
INPUT 2:    CARBOHYDRATE METABOLISM 6 6 3 3 12+6+2

=20

38
INPUT 3:    LIPIDS 5 6 3 3 10+6+2

=18

 35
INPUT 4:   AMINO ACIDS METABOLISM

 

7 6 3 14+6+2

= 22

38
INPUT 5:  ENDOCRINE   SYSTEM 4 3 3 3 8+3+2

=13

26
INPUT 6:   MOLECULAR BIOLOGY, NUCLEIC ACID AND PROTEIN BIOSYNTHESIS

 

12 6 24+6

= 30

48
INPUT 7:    GENETICS

 

3 3 3 6+3+2

=11

20
INPUT 8:   BODY FLUIDS

 

4 3 3

 

8+3+2

=13

23
INPUT 9:     TISSUE BIOCHEMISTRY

 

5 3 9 3 10+3+6

= 19

39
Total 48 36 27 12 0 150 273
17 References 1.           Liebermanns M and Marks AD. Mark’s Basic Medical Biochemistry: A Clinical Approach. Third edition. Lippincotts, Williams and Wilkins Publication. Wolters Kluwer Business. 2009.

2.           Baynes JW and Dominiczak MH. Medical Biochemistry. Third edition. Mosby Elsevier Ltd. 2009.

3.           Rosenthal MD and Glew RH. Medical Biochemistry: Human Metabolism in Health and Diseases. John Wiley and Sons. Hoboken NJ. 2009

4.           Murray R, Bender D, Botham KM, Kennelly PJ, Rodwell V and Weil PA.  Harper’s Illustrated Biochemistry. 28th edition (Lange Basic Science). McGraw-Hill Publication. 2009

5.           Nussbaum RL, Mc Innes RR and Willard HF. Genetics in Medicine. 7th edition, Saunders Co., Thompson and Thompson 2007.